Project Title: Synthetic Chemistry Technologies for Fragment Based Drug Discovery Job Type: 3 year fixed term contract  Astex’s Sustaining Innovation Post-Doctoral research program aims to maintain and further develop the Company’s excellent scientific culture by fostering fundamental research in areas of interest to the drug discove...  more

Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary fragment-based drug discovery (FBDD) platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to two launched oncology drugs (Kisqali...  more

Job Type: Associate Director or above We have an exciting new lab-based role for a highly experienced and creative synthetic organic chemist. Based within the medicinal chemistry department, you will provide expert synthetic chemistry support and leadership across a portfolio of projects and functions ranging from FBDD and synthetic techno...  more

Job Type: 3 year fixed term contract We have exciting opportunities for talented lab-based medicinal chemists keen to work on FBDD in close collaboration with computational chemistry, structural biology, biology and DMPK scientists. Positions are open, for highly motivated PhD chemists, at an early stage in their career, with a strong back...  more

Historically Astex’s fragment screening platform has relied upon X-ray crystallography to support structure-based drug discovery (SBDD), however the increased ability of cryo-EM to deliver atomic resolution structures has led to Astex establishing a state of the art, in-house, cryo-EM facility. This facility includes two Glacios and one Krios t...  more