CT290_01_2019 - Metabolomics Scientist- Industrialisation

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Posted: 16/10/2019 15:15
Start Date: Not Available
Salary: Competitive
Location: Guy's Hospital, London
Level: Industrialisation
Deadline: 28/02/2020 17:00
Hours: 37.5
Benefits: Competitive
Job Type: Permanent

Purpose of Role:

The purpose of this role is to apply in-depth technical expertise across a range of projects to support the development of a nascent metabolomics capability. Working in multidisciplinary teams, the successful candidate will play a central role in applying metabolomics and/or proteomics to accelerate the development of a range of cell and gene therapy products. They will also be an integral part of a wider team supporting the integration of Process Analytical Technologies to develop next generation manufacturing platforms.

Key Accountabilities:

  • Support the establishment of an LCMS platform, including library creation, to enable discovery of metabolomic and proteomics biomarkers
  • Development, validation/qualification of state-of-the-art mass spectrometry assays in support of mechanistic, prognostic and diagnostic analyses in variety of biological matrices
  • Apply expert knowledge of metabolomics datasets to characterise and optimise cell culture processes
  • Perform data analysis on acquired datasets and collaborate with statisticians and data scientists to deliver results
  • Contribute to validation/qualification protocols and reports and present results to internal and external collaborators
  • Adhere to established Standard Operating Procedures, industry practice and regulatory guidance as appropriate
  • Maintain accurate records and manage data in line with company policies
  • Demonstrate competency in troubleshooting, optimisation and implementation of challenging and innovative LC-MS assays

Experience:

  • Strong background in analytical biochemistry/chemistry with emphasis on mass spectrometry applications in metabolomics or proteomics
  • Significant experience in method development, troubleshooting and complex data analysis
  • Strong background in the analysis of omics-based datasets with the use of online databases
  • Proficiency with mass spectrometry software, data analysis software (Spotfire, MATLAB, R, JMP, etc.) word processing, and graphical computer programs
  • Experience with chromatographic separation of various analytes by LC, ion mobility and characterization and quantification by MS or MS/MS
  • Experience of mammalian cell culture and the use of aseptic techniques

Knowledge / Skills / Competencies:

  • The ability to work in a matrix-team environment to contribute expertise and influence the design and planning of laboratory work
  • Ability to work within a fast-paced professional environment, maintaining a high standard of work
  • High degree of motivation, problem solving skills and innovative thinking
  • Excellent oral and written communication skills including technical report writing
  • Ability to work quickly and accurately under limited supervision
  • Good IT skills including experience of using programming languages and data analysis software packages
  • Excellent organisational skills with a strong focus on attention to detail
  • Proven ability to engage constructively with colleagues at all levels across different departments to deliver objectives
  • A good team player easily adaptable to new challenges

Education / Qualifications:

  • PhD in cell biology/biochemistry/chemistry with a strong emphasis on metabolomics or proteomics; or,
  • MSc with 3+ years industrial experience in metabolomics or proteomics within a cell therapy or appropriate Life Science environment


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