KC228 - Research Scientist - Protein Expression & Purification

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Posted: 23/08/2019 14:50
Start Date: Not Available
Salary: Competitive
Location: Babraham Research Campus, Cambridge, UK
Level: Scientific
Deadline: 26/09/2019 23:59
Hours: 35.00
Benefits: Excellent Range of Benefits
Job Type: Permanent

Research Scientist – Protein Expression & Purification (KC228)

Kymab is a clinical-stage biopharmaceutical company developing a deep pipeline of novel antibody-based therapies in a broad range of indications. The Company generates its product candidates using its proprietary, integrated platforms collectively called IntelliSelect®. Kymab’s platforms have been designed to maximize the diversity of human antibodies produced in response to immunization with antigens. Selecting from a broad diversity of fully human antibodies allows for the identification of antibodies with optimal drug-like properties.

We are looking for an enthusiastic laboratory-based protein purification scientist to work in the Purification group providing key reagents to help progress projects to the next stage of development. Mainly focused on antibodies and antibody-based proteins, you will be involved with numerous projects at various stages of research and will have the opportunity to become involved in their development by playing a vital role in this core team.

Key Duties/Responsibilities:

  • Purification of expressed antibodies and proteins from mammalian cell culture
  • Process optimisation and defining purification conditions for more challenging molecular entities
  • Optimising downstream processing
  • Biophysical QC of above material (SEC, SDS-PAGE, Western, etc.)
  • Managing a small team of lab-based scientists
  • Providing support to several projects simultaneously, linking effectively with the project leaders and other scientists as required
  • Clear and accurate data collection and presentation
  • Experience in scale up and scale down processes to aid development work - including use of DoE software
  • Knowledge or experience of platform process design would be advantageous

Job Requirements

Education & Experience:

  • PhD or equivalent in a relevant scientific discipline
  • Good background knowledge of protein biochemistry
  • Experienced in all commonly used protein purification techniques
  • Experienced in use of automated purification equipment (ideally Akta systems)
  • Previous hands-on experience in a bioprocess/method development environment in an industry setting

Skills & Knowledge:

  • Demonstrated innovative thinking to devise strategies to optimise purification processes
  • Ability to work to deadlines and maintain clear and accurate records
  • Innovative thinking, flexibility to adapt quickly and a “can do” attitude
  • Computer literate
  • Strong organisational ability  
  • Ability to work to tight timelines

We offer an excellent range of benefits in addition to an attractive salary package. If you are interested and would like to be considered for the post, please submit your application through our website www.kymab.com. Please upload a covering letter with your CV outlining your suitability for this role by the closing date of 26th September 2019.

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