KC230 - Scientist/Senior Scientist - Drug Product Development

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Posted: 10/09/2019 16:34
Start Date: Not Available
Salary: Competitive
Location: Babraham Research Campus, Cambridge, UK
Level: Scientific
Deadline: 11/10/2019 23:59
Hours: 35.00
Benefits: Excellent range of benefits
Job Type: Permanent

Kymab is a clinical-stage biopharmaceutical company developing a deep pipeline of novel antibody-based therapies in a broad range of indications. The Company generates its product candidates using its proprietary, integrated platforms collectively called IntelliSelect®. Kymab’s platforms have been designed to maximize the diversity of human antibodies produced in response to immunization with antigens. Selecting from a broad diversity of fully human antibodies allows for the identification of antibodies with optimal drug-like properties.

Reporting to the Team Leader of Drug Product Development, we are looking to bring on board an experienced scientist to support the drug product development for Kymab pipeline. This is an exciting opportunity to work in a dynamic and fast-growing environment within the Biopharmaceutical Development (BPD) and build the drug product strategy to enable pre-clinical and clinical studies.

Key Duties/Responsibilities:

You will be responsible for generating data packages to drive the drug product development for Kymab pipeline and help building a seamless internal capability by working closely with downstream, analytical, clinical and regulatory teams. You will be involved in a range of activities, including but not limited to:

  • Contributing to the establishment of new stability indicating assays

  • Performing drug product testing and clinical simulated administration

  • Designing, conducting and interpreting analytical assays (e.g. chromatographic and electrophoretic methods, light scattering) to enable screening stages, product quality analysis and stability testing

  • Performing pre-formulation and formulation studies, force degradation, accelerated and real time studies

  • Providing concise data summary and present outcome to key stakeholders

Job Requirements

Education & Experience:

  • Educated to at least degree level in an Analytical/formulation science, or another relevant degree

  • Previous, relevant bench-based laboratory experience in drug product development of biomolecules (formulation, stability, delivery systems)

  • Experience in lyophilization of biologics (preferable)

  • Experience in drug product fill/finish and labelling processes (desirable)

  • Experience in formulation of bispecific antibodies and non-conventional formats (desirable)

  • Experience in drug product simulated clinical administration compatibility testing (desirable)

Skills & Knowledge:

  • In-depth understanding of protein biochemistry or protein biophysics

  • Experience in protein analytics (e.g. HPLC, SDS PAGE, CE, DLS, SLS) and routine laboratory procedure (e.g. pH, conductivity, spectrometry)

  • Ability to work to tight deadlines, troubleshoot effectively and respond quickly to changes in priority

  • Methodical, organised with an aptitude for detail

  • Demonstrated strengths in planning, organisational, analytical skills, time management and problem solving

  • Ability to work closely with others, encourage good team spirit, motivate a multi-skilled team to higher goals and demonstrate initiative as required

  • A flexible and willing attitude with the desire to continually improve and develop

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