KC264 - Research Associate - Cell Line Development

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Posted: 27/07/2020 14:53
Start Date: Not Available
Salary: Competitive
Location: Babraham Research Campus, Cambridge, UK
Level: Scientific
Deadline: 15/08/2020 23:59
Hours: 35
Benefits: Competitive
Job Type: Permanent

Kymab is a clinical-stage biopharmaceutical company developing a deep pipeline of novel antibody-based therapies in a broad range of indications. The Company generates its product candidates using its proprietary, integrated platforms collectively called IntelliSelect®. Kymab’s platforms have been designed to maximize the diversity of human antibodies produced in response to immunization with antigens. Selecting from a broad diversity of fully human antibodies allows for the identification of antibodies with optimal drug-like properties.

We are looking for an experienced laboratory-based Research Associate to develop our in-house commercial cell line development capabilities. 

Key Responsibilities

  • To develop and optimise a mammalian expression platform (CHO cells) to produce commercially relevant recombinant proteins e.g. antibodies cell lines
  • Evaluating and implementing and troubleshooting new technologies including high-throughput automated cell culture systems
  • Developing high throughput analytical technologies (Octet, icIEF, cSDS, etc.)
  • Molecular biology and cell cloning
  • Authoring of or relevant sections of regulatory submissions. 
  • Contribute and lead on-going process development within the group
  • Clear and accurate record keeping
  • Other duties as may be required

 

Job Requirements

Education and Experience

  • BSc/MSc or equivalent in cell or molecular biology/biotechnology
  • Relevant experience in commercial cell culture in an industry collaboration or within an industry setting
  • Strong aseptic technique

Desirable

  • Commercial cell line development for recombinant protein expression within an industry setting
  • Automated data capture, analysis and visualisation
  • Experienced in small scale protein purification
  • Experienced in regulatory submissions process
  • Tech transfer experience

 

Skills and Knowledge

  • Ability to work effectively within a team environment, working collaboratively across the group
  • Ability to devise strategies to optimise expression
  • A high level of motivation, innovative thinking, flexibility to adapt quickly and a “can do” attitude.
  • Ability to work to tight timelines, process several projects simultaneously and link effectively with project leaders and other scientists as required


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