KC216 - Research Scientist - Protein Expression & Purification

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Posted: 20/05/2019 11:48
Start Date: Not Available
Salary: Competitive
Location: Babraham Research Campus, Cambridge, UK
Level: Scientific
Deadline: 17/06/2019 23:59
Hours: 35.00
Benefits: Excellent Range of Benefits
Job Type: Permanent

Kymab is a leading biopharmaceutical company focused on the discovery and development of fully human monoclonal antibody drugs using its proprietary IntelliSelect® antibody platform. Kymab was founded in 2010 and has since raised over US$220m of equity financing to advance several therapeutic antibody programmes in immune-oncology, auto-immunity, haematology and infectious disease. More information about Kymab can be found at www.kymab.com.

We are looking for an enthusiastic laboratory-based protein purification scientist to work in the Purification group providing key reagents to help progress projects to the next stage of development. Mainly focused on antibodies and antibody-based proteins, you will be involved with numerous projects at various stages of research and will have the opportunity to become involved in their development by playing a vital role in this core team.

Key Duties/Responsibilities:

  • Purification of expressed antibodies and proteins from mammalian cell culture
  • Process optimisation and defining of purification conditions for more challenging molecular entities
  • Optimising work flow, process development and output
  • Biophysical QC of above material (SEC, SDS-PAGE, Western, etc.)
  • Managing a small team of lab-based scientists
  • Providing support to several projects simultaneously, linking effectively with the project leaders and other scientists as required
  • Clear and accurate data collection and presentation
  • Experience in scale up and scale down processes to aid development work
  • Knowledge or experience of platform process design would be advantageous

Job Requirements

Education & Experience:

  • PhD or equivalent in a relevant scientific discipline
  • Good backgroundn knowledge of protein biochemistry
  • Experienced in all commonly used protein purification techniques
  • Experienced in use of automated purification equipment (ideally Akta systems)

Skills & Knowledge:

  • Demonstrated innovative thinking to devise strategies to optimise purification processes
  • Ability to work to deadlines and maintain clear and accurate records
  • Innovative thinking, flexibility to adapt quickly and a “can do” attitude
  • Computer literate
  • Strong organisational ability  
  • Ability to work to tight timelines


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