KC257 - Director - Research Immunology

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Posted: 08/04/2020 14:42
Start Date: Not Available
Salary: Competitive
Location: Babraham Research Campus, Cambridge, UK
Level: Management
Deadline: 30/10/2020 23:59
Hours: 35.00
Benefits: Excellent range of benefits
Job Type: Permanent

Kymab is a clinical-stage biopharmaceutical company developing a deep pipeline of novel antibody-based therapies in a broad range of indications. The Company generates its product candidates using its proprietary, integrated platforms collectively called IntelliSelect®. Kymab’s platforms have been designed to maximize the diversity of human antibodies produced in response to immunization with antigens. Selecting from a broad diversity of fully human antibodies allows for the identification of antibodies with optimal drug-like properties.

As the Director of Research Immunology at Kymab, you will be leading the development of new models, assays & capabilities to drive the progression of projects within Kymab’s immunology-focussed portfolio, continuing to develop our immune-oncology & auto-immunity projects.

Working with the SVP of Research Immunology, you’ll refine Kymab’s strategy in immune-oncology and auto-immune disease drug discovery, developing Kymab’s capabilities by introducing new technologies and demonstrating your own expertise & decision-making to drive project progression.

You’ll be a subject matter expert for the team and company more broadly, maintaining an in-depth understanding of fundamentals of immunology, immuno-oncology & tumour biology

It’s expected you’ll be able to communicate with and successfully influence senior level management, executives & stakeholders at all levels as well as leading and developing a team of talented scientists, bioinformaticians & technicians.

Key Responsibilities

Lead projects and multi-functional teams

  • Lead capability development and the assessment and validation of novel targets in Kymab’s chosen research areas.
  • Work with a multidisciplinary team to plan and execute preclinical in vitro and in vivo experiments supporting biological and mechanistic understanding of our molecules.
  • Write patents and contribute to the generation of regulatory documentation (e.g. in support of molecules progressing to clinical development).
  • Identify opportunities and lead the authorship of peer reviewed manuscripts and presentation of original work at scientific conferences and symposia
  • Work effectively with external groups including collaborators and CRO
  • Critically analyse, interpret, and report experimental results, draw appropriate conclusions and design next experimental steps driving project progression.
  • Active presentation of findings at internal and external meetings

Manage a team of scientists

  • Lead the in vivo effort and lead the team to develop new models and deliver preclinical efficacy in vivo proof of concept and evaluate detailed analysis of our novel molecules mechanism of action in the context of disease
  • Demonstrate the ability to enthuse and motivate a multi-disciplinary team

Job Requirements

Education & Experience

  • PhD in Immunology, Cancer Biology or equivalent industrial experience
  • Demonstrable leadership experience
  • In depth knowledge of in vivo oncology models
  • Good publication record
  • Extensive experience of supporting late stage antibody discovery into early stage development

Strongly Preferred

  • In depth knowledge & understanding of pre-clinical research objectives to drive project progression in immune-oncology & auto-immune disease
  • Demonstrable track record of successful research supported by publications (peer reviewed publications, oral presentations, posters & patent filings)

Skills & Knowledge

  • Excellent presentation skills
  • Strong motivation & team spirit
  • Demonstrable leadership capabilities
  • Strong knowledge of oncology and immunology
  • Ability to multitask and work to competing deadlines
  • In depth knowledge of antibody drug development


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